Formulation and Evaluation of Nicotine Polacrilex Chewable Tablets by Direct Compression
DOI:
https://doi.org/10.22270/ajprd.v14i3.1754Abstract
Nicotine polacrilex chewable tablets were developed as an effective dosage form for nicotine replacement therapy to help reduce smoking dependence. The present study focused on the formulation and evaluation of chewable tablets using suitable excipients to improve taste, stability, and drug release. Tablets were prepared by the direct compression method using ingrediaents such as mannitol, microcrystalline cellulose, sodium starch glycolate, and flavouring agents. Pre-compression studies indicated good flow properties of the powder blend, ensuring uniform tablet formation. The prepared tablets were evaluated for various parameters including weight variation, hardness, friability, thickness, disintegration time, and in-vitro drug release. All formulations complied with pharmacopeial limits, showing acceptable mechanical strength and rapid disintegration. Among the formulations, batch NT4 showed the best performance with optimum hardness, lowest friability, and faster disintegration time. In-vitro dissolution studies demonstrated effective drug release within a short period, indicating suitability for rapid nicotine delivery. Overall, the developed chewable tablets offer a convenient, patient-friendly, and effective approach for nicotine replacement therapy.
Downloads
References
Prakash AA, Soni PK, Paswan SK, Saini TR. Formulation and optimization of mucoadhesive buccal film for nicotine replacement therapy. Int J App Pharm. 2023 Mar;15(3):100-12. DOI: https://doi.org/10.22159/ijap.2023v15i3.47412
Namannavar S, Patil CC, Uppar AL, Jakaraddi S. Design and characterization of Nicotine Polacrilex-Loaded Cubosomal Nanogel for enhanced topical drug delivery. Journal of Drug Delivery and Therapeutics. 2026 Apr 15;16(4):8–15. https://doi.org/10.22270/jddt.v16i4.7657
Bhusnure O, Shaikh F, Sugave B, Kavale B, Sayyed R, Hucche B. Formulation strategies for taste-masking of chewable tablets. Am. J. Pharm. Res. 2015;5:3836-49.
Mutha S, Kshirsagar C, Shelke V, Sawant S. Formulation, development and evaluation of chewable tablet of dicyclomine hydrochloride. Int J Health Sci. 2022;6(S7):1224-36. DOI: https://doi.org/10.53730/ijhs.v6nS7.11430
Farheen F, Bharadwaj S. Formulation and evaluation of chewable tablets of mebendazole by different techniques. PharmaTutor. 2014 Jun 1;2(6):183-9.
Srivatsa PS, Deeksha J, Harpreeth S, Sahithi B, Nandini BS, Nithya PD, Abbulu K. Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder. Journal of Drug Delivery & Therapeutics. 2020 May 1;10(3):58-64. DOI: https://doi.org/10.22270/jddt.v10i3.4069
Khairnar U, Chole R, Hire R, Bharti G. Development of A Novel Herbal Chewable Tablet for Dental Caries Treatment. International Journal of Scientific Research and Technology. 2025 Jan 27.
Jagdale S, Gattani M, Bhavsar D, Kuchekar B, Chabukswar A. Formulation and evaluation of chewable tablet of levamisole. Int. J. Res. Pharm. Sci. 2010;1(3):282-9.
Dahiya J, Jalwal P, Arora S, Singh B. Formulation and evaluation of chewable tablets of loratadine by direct compression method. The Pharma Innovation. 2015 Jul 1;4(5, Part B):97.
Muhammad A, Musharraf A, Fatima T, Rabiya Y, Muhammad N. Formulation and evaluation of chewable tablets of Desloratadine prepared by aqueous and non-aqueous techniques. Journal of Drug Delivery & Therapeutics. 2020 Jan 1;10(1):5-10. DOI: https://doi.org/10.22270/jddt.v10i1.3796
Gaikwad VD, Thorat PA, Ghogaon S. Formulation and evaluation of poly herbal chewable tablets from Ayurvedic ingredients having cough relieving activity. Int J Innovative Sci Res Technol. 2023;8(4):1872-9.
Sawatdee S, Atipairin A, Sae Yoon A, Srichana T, Changsan N, Suwandecha T. Formulation development of albendazole-loaded self-microemulsifying chewable tablets to enhance dissolution and bioavailability. Pharmaceutics. 2019 Mar 20;11(3):134. DOI: https://doi.org/10.3390/pharmaceutics11030134
Amrutkar PP, Patil SB, Todarwal AN, Wagh MA, Kothawade PD, Surawase RK. Design and evaluation of taste masked chewable dispersible tablet of lamotrigine by melt granulation. International Journal of Drug Delivery. 2010 Apr 1;2(2):183-91.
Navapariya V, Thosar MM, Zinzuvadiya M, Rathava D, Pathak D. UV Spectrophotometric Method for Estimation of Pure Nicotine. Journal of Drug Delivery & Therapeutics. 2025 Apr 1;15(4).DOI: https://doi.org/10.22270/jddt.v15i4.7028
Tessema TA, Kassa FM, Joseph NM. Characterization and evaluation of the fruit mucilage of Cordia africana as tablet binder in paracetamol tablet formulation: optimization study. Scientific Reports. 2025 Oct 27;15(1):37479. DOI: https://doi.org/10.1038/s41598-025-21427-2
Published
How to Cite
Issue
Section
Copyright (c) 2026 Shashank Namannavar, Sneha R Jakaraddi, Dr. Chandrashekar C. Patil, Arjun L Uppar
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
. 