A Comprehensive Review on SNEEDS: A Simple Tool to Enhance Drug Solubility
DOI:
https://doi.org/10.22270/ajprd.v14i3.1775Abstract
Many new and current therapeutic compounds still face significant obstacles in their oral delivery due to poor solubility in water, due to this there is poor dissolution, ineffective absorption, and low bioavailability. One of the most promising lipid-based technologies among the different formulation techniques investigated to overcome these constraints is Self-Nanoemulsifying Drug Delivery Systems (SNEDDS). SNEDDS is mixtures of oils, surfactants, and co-surfactants. when this exposed to gastrointestinal fluids it rapidly and spontaneously undergo nanoemulsification, producing ultra-fine droplets that maintain the solubility of lipophilic medications. This review offers a thorough overview of SNEDDS, covering their underlying mechanisms, formulation components, physicochemical factors controlling self-emulsification, and selection criteria for appropriate drug candidates.
The importance of pseudoternary phase diagrams in optimizing compositions, the wide range of approaches to characterization that determine their structural and functional performance and both traditional and sophisticated methods for SNEDDS preparation are all summarized in the article. The review also discusses the current issues with scale-up, stability, and clinical translation, as well as the benefits, drawbacks, and broad pharmaceutical applications of both liquid and solid SNEDDS. So these is versatile platform to enhance the therapeutic effectiveness of poorly water-soluble medications can be seen by emerging trends in computational modeling, quality-by-design techniques, and alternative administration routes.
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